In 2010, Lambda Theta Alpha officially became a collegiate partner to St. Jude Children’s Research Hospital in an effort to have a larger and more united impact on a national philanthropic cause. The sorority is the first and only Latino Greek organization to commit to the hospital’s efforts to bring awareness to childhood cancer, life-threatening diseases and St. Jude within the Latino community and to fundraise for the hospital through a variety of events and programs.

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In 2014, the sorority expanded its partnership with St. Jude by becoming an official partner of the annual St. Jude Walk/Run to End Childhood Cancer, which brings communities together across the nation during Childhood Cancer Awareness Month to raise funds for the hospital. The sorority has repeatedly exceeded its sponsorship commitments and looks forward to this event every year.